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Zentralinstitut für Ernährungs- und Lebensmittelforschung (ZIEL)

Abteilung Mikrobiologie
Technische Universität München
Weihenstephaner Berg 3
D-85350 Freising

PD Dr. Klaus Neuhaus, Biologist
 
 
Phone: +49-8161-71 5549
E-mail: neuhaus@wzw.tum.de
 
 
Research and professional career
 
 
  • 1991 – 1996 Studies in biology (botany, zoology, organic chemistry) at the Johann-Wolfgang-Goethe-University in Frankfurt am Main.
     
  • 1996  Diploma thesis in the research group "Mycology and Phytopathology" (Prof. Jutta Ludwig-Müller): "Northern analysis of nitrilase mRNA in transgenic Arabidopsis thaliana after infection with Plasmodiophora brassicae".
     
  • 1996 – 2000 Doctorate in the research group of Prof. Siegfried Scherer, Institute for Microbiology, Technical University Munich, Freising, Germany.
     
  • 2000 Dr.rer.nat. in Microbiology: "Characterization of major cold shock protein genes of the psychrotolerant food pathogens Bacillus weihenstephanensis and Yersinia enterocolitica".
     
  • 2000 – 2001 Postdoc at the Institute for Microbiology, Technical University Munich, Germany:  "Cold shock response in food-borne pathogens and lux reporter studies".
     
  • 2001 – 2003 Postdoc at the Department of Molecular Microbiology, Group of Prof. Virginia Miller, Washington University in St. Louis (USA): "Yersinia enterocolitica - Major cold shock protein regulation and RscBAC adhesin studies in mice" 
     
  • 2003 - 2010 Group leader of the group: “Molecular biology of food-borne pathogens in the environment and in the food chain”
  • 2016 Habilitation in Microbiology: "Molecular ecology of food-borne bacteria in the environment and food chain - Bacterial interpenetration of trophic level" Technical University Munich


    publication list 

    Fellner L, Huptas C, Simon S, Mühlig A, Scherer S, Neuhaus K (2016) Draft genome sequences of three European laboratory derivatives from enterohemmorrhagic Escherichia. coli  O157:H7 strain EDL933, including two plasmids.Genome Announcements 4(2):e01331-15

    Neuhaus K, Landstorfer R, Fellner L, Simon S, Schafferhans A, Goldberg T, Marx H, Ozoline ON, Rost B, Kuster B, Keim DA, Scherer S (2016) Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC). BMC Genomics 17:133

    Fellner L, Simon S, Scherling C, Witting M, Schober S, Polte C, Schmitt-Kopplin P, Keim DA, Scherer S, Neuhaus K (2015) Evidence for the recent origin of a bacterial protein-coding, overlapping orphan gene by evolutionary overprinting. BMC Evol Biol. 15:283 

    Simon S, Mittelstädt S, Kwon BC, Stoffel A, Landstorfer R, Neuhaus K, Mühlig A, Scherer S, Keim DA (2015) VisExpress: Visual exploration of differential gene expression data. Info Vis, 
    14:1473871615612883

    Landstorfer R, Simon S, Schober S, Keim D, Scherer S, Neuhaus K (2014) Comparison of strand-specific transcriptomes of enterohemorrhagic Escherichia coli O157:H7 EDL933 (EHEC) under eleven different environmental conditions including radish sprouts and cattle feces. BMC Genomics 15:353

    Fellner L, Bechtel N, Witting MA, Simon S, Schmitt-Kopplin P, Keim D, Scherer S, Neuhaus K (2014) Phenotype of htgA (mbiA), a recently evolved orphan gene of Escherichia coli and Shigella, completely overlapping in antisense to yaaW. FEMS Microbiol Lett 350:57-64

    Mir K, Neuhaus K, Bossert M, Schober S (2013) Short Barcode for Next Generation Sequencing. PLoS ONE 8(12):e82933 

    Neuhaus K, Satorhelyi P, Schauer K, Scherer S, Fuchs TM (2013) Acid shock of Listeria monocytogenes at low environmental temperatures induces prfA, epithelial cell invasion, and lethality towards Caenorhabditis elegans. BMC Genomics, 14:285.

    Lang Halter E, Neuhaus K, Scherer S (2013) Listeria weihenstephanensis sp.nov., isolated from the water plant Lemna trisulca of a German fresh water pond. Int. J. Syst. Evol. Microbiol., 63(2):641–647. 

    Fuchs T, Neuhaus K, Scherer S (2013) Life at Low Temperatures. In: M. Dworkin et al., eds., The Prokaryotes,  Springer Verlag, Berlin Heidelberg.

    Schober S, Mir K, Neuhaus K, Bossert M (2012) Design of Short Barcodes for Next Generation Sequencing of DNA and RNA. In: IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), pp. 31–34, Washington DC, USA, doi:10.1109/GENSIPS.2012.6507719.

    Mir K, Neuhaus K, Scherer S, Bossert M, Schober S (2012) Predicting statistical properties of open reading frames in bacterial genomes. PLoS ONE 7(9):e45103. 

    Simon S, Oelke D, Landstorfer R, Neuhaus K, Keim D (2011) Visual Analysis of Next-Generation Sequencing Data to Detect Overlapping Genes. In:  IEEE Symposium on Biological Data Visualization, pp. 47–54, Providence, Rhode Island, USA.

    Oelke D, Janetzko H, Simon, S, Neuhaus K, Keim DA (2011) Visual Boosting in Pixel-based Visualizations. Comput Graph Forum 30:871-880.

    Samelis J, Bleicher A, Delbès-Paus C, Kakouri A, Neuhaus K, Montel M-C (2010) FTIR-based polyphasic identification of lactic acid bacteria isolated from traditional Greek Graviera cheese. Food Microbiol., 28(1):76-83. 

    Bleicher A, Stark T, Hofmann T, Bogovic Matijasic B, Rogelj I, Scherer S, Neuhaus K (2010) Potent antilisterial cell-free supernatants produced by complex red smear cheese microbial consortia. J. Dairy Sci., 93(10):4497-4505.

    Bleicher A, Obermajer T, Bogovic Matijasic B, Scherer S, Neuhaus K (2010) High biodiversity and potent anti-listerial action of complex red smear cheese microbial ripening consortia. Ann. Microbiol., 60(3):531-539.

    Neuhaus K, Oelke D, Fürst D, Scherer S, Keim DA (2010) Towards automatic detecting of overlapping genes - Clustered BLAST analysis of viral genomes.  Lect. Notes Comput. Sci. 6023:228–239.

    Bleicher A, Neuhaus K, Scherer S (2010) Vibrio casei sp. nov., isolated from the surface of two French red smear soft cheeses. Int.J. Syst. Evol. Microbiol 60(Pt.8):1745-1749 

    Monnet C, Bleicher A, Neuhaus K, Sarthou A-S, Leclercq-Perlat M-N, Irlinger F (2009) Assessment of the anti-listerial activity of microfloras from the surface of smear-ripened cheeses. Food Microbiol. 27(2): 302-3010


    Hain T, Chatterjee SS, Ghai R, Kuenne CT, Billion A, Steinweg C, Domann E, Kärst U, Jänsch L, Wehland J, Eisenreich W, Bacher A, Joseph B, Schär J, Kreft J, Klumpp J, Loessner MJ, Dorscht J, Neuhaus K, Fuchs TM, Scherer S, Doumith M, Jacquet C, Martin P, Cossart P, Rusniock C, Glaser P, Buchrieser C, Goebel W, Chakraborty T. (2007) Pathogenomics of Listeria spp. Int. J. Medical Microbiol. 297, 541-557.

    Jakob K, Satorhelyi P, Lange C, Wendisch VF, Silakowski B, Scherer S, Neuhaus K (2007) Gene expression analysis of long-term lactic acid adapted Corynebacterium glutamicum. J.Bacteriol, J. Bacteriol. 189, 5582-5590.
     

    Loessner H, Endmann A, Leschner S, Westphal K, Rohde M, Miloud T, Hämmerling G, Neuhaus K, Weiss S (2007) Remote control of tumor targeted Salmonella enterica serovar Typhimurium - L-arabinose as inducer of bacterial gene expression in vivo. Cell. Microbiol. 9, 1529-1537.

    Keim DA, Oelke D, Truman R, Neuhaus K (2006) Finding correlations in functionally equivalent proteins by integrating automated and visual data exploration. Proc. Sixth IEEE Symp. BioInformatics BioEngineering 0, 183-192.


    Bresolin G, Neuhaus K, Scherer S, Fuchs TM (2006) Transcriptional analysis of long-term adaptation of Yersinia enterocolitica to low-temperature growth.J. Bacteriol. 188, 2945-2958.


    Scherer S,
    Neuhaus K (2006) Life at low temperatures. in Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E, eds., The Prokaryotes: A Handbook on the Biology of Bacteria. Vol. 2: Ecophysiology and Biochemistry, 3rd edition, October 6, 2006, Springer-Verlag, New York. 

    Neuhaus K
    , Anastasov N, Kaberdin V, Francis KP, Miller VL, Scherer S (2003) The AGUAAA motif in cspA1/A2 mRNA is important for adaptation of Yersinia enterocolitica to grow at low temperature. Mol. Microbiol. 50, 1629-1645.
     
    Maoz A, Mayr R, Bresolin G, Neuhaus K, Francis KP, Scherer S (2002) Sensitive in situ monitoring of a recombinant bioluminescent Yersinia enterocolitica reporter mutant in real time on Camembert cheese. Appl. Environ. Microbiol. 68, 5737-5740.
     
    Neuhaus K, Rapposch S, Francis KP, Scherer S (2000) Restart of exponential growth of cold-shocked Yersinia enterocolitica occurs after down-regulation of cspA1/A2 mRNA. J. Bacteriol. 182, 3285-3288.
     
    Neuhaus K, Grsic-Rausch S, Sauerteig S, Ludwig-Müller J (2000) Arabidopsis plants transformed with nitrilase 1 or 2 in antisense direction are delayed in clubroot development. J. Plant Phys. 156, 756-761.
     
    Neuhaus K (2000) Characterization of major cold shock protein genes of the psychrotolerant food pathogens Bacillus weihenstephanensis and Yersinia enterocolitica. Univ. Diss. Technische Universität München; Hieronymus, München, ISBN 3-89791-124-8.
     
    Neuhaus K Francis KP, Rapposch S, Görg A, Scherer S (1999) Pathogenic Yersinia species carry a novel, cold-inducible major cold shock protein tandem gene duplication producing both bicistronic and monocistronic mRNA. J. Bacteriol. 181, 6449-6455.
     
    von Stetten F, Francis KP, Lechner S, Neuhaus-K, Scherer S (1998) Rapid discrimination of psychrotolerant and mesophilic strains of the Bacillus cereus group by PCR targeting of 16S rDNA. J. Microbiol. Methods 34, 99-106.
     
    Grsic S, Sauerteig S, Neuhaus K, Albrecht M, Rossiter J, Ludwig-Müller J (1998). Physiological analysis of transgenic Arabidopsis thaliana plants expressing one nitrilase isoform in sense or antisense direction. J. Plant Physiol. 153, 446-456.
     
     
     
     
     
     
     
     

    Aktuelles

    Stellenausschreibung
    PhD student position by end of October 2017 Adaptation and Constraint in the Evolution of Overlapping Genes

    Forschungspreis
    Otto-von-Guericke Forschungspreis für Siegfried Scherer

    Preisverleihung
    Innovationspreis für Siegfried Scherer

    Paper
    Spoilage of Microfiltered and Pasteurized Extended Shelf Life Milk Is Mainly Induced by Psychrotolerant Spore-Forming Bacteria that often Originate from Recontamination (2017)

    Paper
    Transcriptional and translational regulation by RNA thermometers, riboswitches and the sRNA DsrA in Escherichia coli O157:H7 Sakai under combined cold and osmotic stress adaptation. (2016)

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    Hysteresis in myo-inositol utilization by Salmonella Typhimurium (2016)

    Paper
    Probiotic Enterococcus faecalis Symbioflor® down regulates virulence genes of EHEC in vitro and decrease pathogenicity in a Caenorhabditis elegans model (2017)

    Paper
    Draft Genome Sequence of Lysinibacillus xylanilyticus SR-86 (Nov. 2016)

    Paper
    Permanent colonization of creek sediments, creek water and limnic water plants by four Listeria species in low population densities (November 2016)

    Paper
    Draft Genome Sequence of the Xanthan Producer Xanthomonas campestris LMG 8031 (Oktober 2016)

    Paper
    Comparative Bioinformatics and Experimental Analysis of the Intergenic Regulatory Regions of Bacillus cereus hbl and nhe Enterotoxin Operons and the Impact of CodY on Virulence Heterogeneity (Mai 2016)

    Paper
    Regulation of fucose and 1,2-propanediol utilization by Salmonella enterica serovar Typhimurium (März 2016)

    Paper
    Acidified nitrite inhibits proliferation of Listeria monocytogenes - Transcriptional analysis of a preservation method (März 2016)

    Berufung Expertenrat
    Prof. Dr. Siegfried Scherer wurde in den Expertenrat für Lebensmittelsicherheit des Bayerischen Staatsministeriums für Umwelt und Verbraucherschutz berufen.

    Paper
    Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC)

    Paper
    A sensitive and robust method for direct determination of lipolytic activity in natural milk environment (März 2016, online first)

    Paper
    Evidence for the recent origin of a bacterial protein-coding, overlapping orphan gene by evolutionary overprinting (Dez. 2015).

    Paper
    Massive horizontal gene transfer, strictly vertical inheritance and ancient duplications differentially shape the evolution of Bacillus cereus enterotoxin operons hbl, cytK and nhe (Nov. 2015)

    Paper
    Chemodiversity of cereulide, the emetic Toxin of Bacillus cereus (2015)