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Zentralinstitut für Ernährungs- und Lebensmittelforschung (ZIEL)

Abteilung Mikrobiologie
Technische Universität München
Weihenstephaner Berg 3
D-85350 Freising


Evolutionary biology

Prof. Dr. Siegfried Scherer
and coworkers

First, based on a variety of microbiological and molecular biological experimental strategies as well as bioinformatical analyses we study the presence, origin and evolution of overlapping genes in bacteria (see research groups functional characterization and bioinformatics and evolution).


Secondly, I am also interested in the broader theoretical analysis of evolutionary processes. What kinds of microevolutionary changes can be observed? How far-reaching are they? How fast do they occur? Which changes in biological information result from such processes? Have microevolutionary mechanisms been observed which are suitable to explain macroevolutionary transitions or does macroevolution involve additional factors?

Thirdly, I find it quite useful to evaluate the epistemological background of empirical theories (e.g., mechanisms of microevolutionary changes) and empirical-historical theories such as macroevolutionary transitions. 



Selected Publications

Hücker SM, Vanderhaegen S, Abellan-Schneyder I, Wecko R, Simon S, Scherer S , Neuhaus K (2018) A novel short L-arginine responsive protein-coding gene (laoB) antiparallel overlapping to a CadC-like transcriptional regulator in Escherichia coli O157:H7 Sakai originated by overprinting. BMC Evolutionary Biology, BMC Evolutionary Biology 18:21. doi: 10.1186/s12862-018-1134-0

Scherer S (2017) Denkvoraussetzungen und weltanschauliche Überzeugungen in der Biologie. In: Lüke U, Souvignier G (Hrsg) Wie objektiv ist Wissenschaft? WBG Darmstadt, S. 45-80.

Böhm M-E, Huptas C, Krey V, Scherer S (2015) Massive horizontal gene transfer, strictly vertical inheritance and ancient duplications differentially shape the evolution of Bacillus cereus enterotoxin operons hbl, cytK and nhe. BMC Evolutionary Biology 15:246   

Fellner L, Simon S, Scherling C, Witting M, Schober S, Polte C, Schmitt-Kopplin P, Keim DA, Scherer S, Neuhaus K (2015) Evidence for the recent origin of a bacterial protein-coding, overlapping orphan gene by evolutionary overprinting. BMC Evolutionary Biology 15:283.

Scherer S (2010) Hat die Biologie das Leben erklärt? In: Thim-Mabrey C, Brack-Bernsen L, Täuber D (Hrsg.) Naturwissenschaftliche Aussagen und sozial verantwortbare Entscheidungen. Noderstedt 2010. Seite 133-183
 
Scherer S (2009) Makroevolution molekularer Maschinen: Konsequenzen aus den Wissenslücken evolutionsbiologischer Naturforschung. In: Hahn HJ, McClary R, Thim-Mabrey C (Hrsg.) Atheistischer und jüdisch-christlicher Glaube: Wie wird Naturwissenschaft geprägt? Forschungssymposium vom 02.-04.04.2008 an der Universität Regensburg, Noderstedt, Seite 95-149

Fuchs TM, Bresolin G, Marcinowski L, Schachtner J, Scherer S (2008) Insecticidal genes of Yersinia spp.: taxonomical distribution, contribution to toxicity towards Manduca sexta and Galleria mellonella, and evolution. BMC Microbiology 8:214.
 
Ehling-Schulz M, Svensson B, Guinebretiere MH, Lindback T, Andersson M, Schulz A, Fricker M, Christiansson A, Granum PE, Martlbauer E Nyguyen-The C, Salkinoja-Salonen M and S. Scherer S (2005) Emetic toxin formation of Bacillus cereus is restricted to a single evolutionary lineage of closely related strains. Microbiology 151:183-197 

Loewe L, Textor V, Scherer S (2003) High deleterious genomic mutation rate in stationary phase of Escherichia coli. Science 302, 1558-1560.

Scherer S, Lechner S, Böger P (1993) psbD sequences of Bumilleriopsis filiformis (Heterokontophyta, Xanthophyceae) and Porphyridium purpureum (Rhodophyta, Bangiophycidae): evidence for polyphyletic origin of plastids. Current Genetics 24: 437-442.


Scherer S, Herrmann G, Hirschberg J, Böger P (1991) Evidence for multiple xenogenous origins of plastids: Comparison of psbA genes with a xanthophyte sequence. Current Genetics 19: 503-507.

Scherer S (1990) The protein molecular clock: Time for a re-evaluation. Evolutionary Biology 24, 83-106.

Scherer S (1989) The relative rate test of molecular evolution: A note of caution. Molecular Biology and Evolution 6, 436-441.

Scherer S (1983) Basic functional states in the evolution of cyclic photosynthetic electron transport. Journal of Theoretical Biology 104, 289-299.



News

Paper
Optimality in the standard gentic code is robust with respect to comparison code sets (2019)

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Accurate quantification of thermophilic spores in dairy powders (2019)

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Pseudomonas lactis sp. nov. and Pseudomonas paralactis sp. nov., isolated from bovine raw milk (2017)

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Resistance of thermophilic spore formers isolated from milk and whey products towards cleaning-in-place conditions: Influence of pH, temperature and milk residues (2019)

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Proposal of Lysobacter pythonis sp. nov. isolated from royal pythons (Python regius) (2019)

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The novel EHEC gene asa overlaps the TEGT transporter gene in antisense and is regulated by NaCl and growth Phase (Dec 2018)

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The small RNA RssR regulates myo-inositol degradation by Salmonella enterica (Dec.2018)

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Activity of a Holin-Endolysin System in the Insecticidal Pathogenicity Island of Yersinia enterocolitica (2018)

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Reprogramming Human Siderocalin to Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus (2018)

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Insecticidal Toxicity of Yersinia frederiksenii Involves the Novel Enterotoxin YacT (2018)

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Dysfunction, Disease, and the Limits of Selection (2018)

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Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli (2018)

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Genome sequence of the novel virulent bacteriophage PMBT14 with lytic avtivity against Pseudomonas fluorescens DSM 50090 (2018)

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The Novel Anaerobiosis-Responsive Overlapping Antisense to the Annotated Gene ECs2385 of Escherichia coli O157:H7 Sakai (Mai 2018)

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Thermal treatment of skim milk concentrates in a novel shear-heating device: Reduction of thermophilic spores and physical properties (Febr. 2018)

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A novel short L-arginine responsive protein-coding gene (laoB) antiparallel overlapping to a CadC-like transcriptional regulator in Escherichia coli O157:H7 Sakai originated by overprinting (2018)

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Thermal resistance of vegetative thermophilic spore forming bacilli in skim milk isolated from dairy Environments (2017)

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Comparison between Listeria sensu stricto and Listeria sensu lato strains identifies novel determinants involved in infection (2017)

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Differentiation of ncRNAs from small mRNAs in Escherichia coli O157:H7 EDL933 (EHEC) by combined RNAseq and RIBOseq-ryhB encodes the regulatory RNA RyhB and a Peptide, RyhP. (2017)

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Complete circular genome sequence and temperature independent adaptation to Anaerobiosis of Listeria weihenstephanensis DSM 24698 (2017)

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Discovery of numerous novel small genes in the intergenic regions of the Escherichia coli O157:H7 Sakai Genome (2017)

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Spoilage of Microfiltered and Pasteurized Extended Shelf Life Milk Is Mainly Induced by Psychrotolerant Spore-Forming Bacteria that often Originate from Recontamination (2017)

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Transcriptional and translational regulation by RNA thermometers, riboswitches and the sRNA DsrA in Escherichia coli O157:H7 Sakai under combined cold and osmotic stress adaptation. (2016)

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Comparative Bioinformatics and Experimental Analysis of the Intergenic Regulatory Regions of Bacillus cereus hbl and nhe Enterotoxin Operons and the Impact of CodY on Virulence Heterogeneity (Mai 2016)

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Acidified nitrite inhibits proliferation of Listeria monocytogenes - Transcriptional analysis of a preservation method (März 2016)

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Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC)

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Evidence for the recent origin of a bacterial protein-coding, overlapping orphan gene by evolutionary overprinting (Dez. 2015)

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Massive horizontal gene transfer, strictly vertical inheritance and ancient duplications differentially shape the evolution of Bacillus cereus enterotoxin operons hbl, cytK and nhe (Nov. 2015)